Research benefits
- Supports mitochondrial function and cellular energy
- Activates sirtuins (SIRT1–SIRT7) linked to longevity signalling
- Supports DNA repair via PARP enzymes
- Early human trials show improved energy and clarity in middle-aged adults
- May support neurological resilience and metabolic flexibility
- Typical protocol pairs well with resistance training and sleep hygiene
How it works
NAD+ acts as an electron carrier in redox reactions — it accepts electrons during glycolysis and the Krebs cycle, then donates them to drive ATP synthesis. Beyond energy, it is the required substrate for sirtuins (which regulate gene expression), PARPs (which repair DNA damage), and CD38 (immune modulation). Exogenous NAD+ can bypass age-related declines in its natural biosynthesis pathways.
Dosage and administration
Research protocols vary widely. Subcutaneous injections typically use 50–100 mg per dose once daily for 10–30 days, then cycle. Intravenous infusions of 250–500 mg over several hours are also reported in private clinics. Start low (25 mg) and titrate — flushing and nausea are common at higher doses and can be mitigated by slower administration.
References
See PubMed for peer-reviewed NAD+ research. Key authors: Sinclair DA, Imai S, Verdin E.
Calculate your NAD+ dose
Use our free reconstitution calculator for exact draw units, half-life curves, and cycle schedules.
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